Air strikes on Aleppo hospital kill doctors and children

Air strikes destroyed a hospital and killed dozens of people in rebel-held areas of Aleppo, including children and doctors, in an attack that a US official said appeared to be solely the work of the Syrian government.

The city of Aleppo is at the center of a military escalation that has undermined peace talks in Geneva aimed at ending the five-year-old war.

UN envoy Staffan de Mistura appealed to the presidents of the United States and Russia to intervene to salvage a ceasefire that was "barely alive". The truce is intended to allow an opportunity for peace talks and delivery of humanitarian relief.

Six days of air strikes and rebel shelling in Aleppo, which is split between government and rebel forces, have killed 200 people, two-thirds of them on the opposition side, the Syrian Observatory for Human Rights says.

The "catastrophic deterioration" in Aleppo over the last 24 to 48 hours has jeopardized the aid lifeline that supplies millions of Syrians, said Jan Egeland, chairman of the UN humanitarian task force. 

The US State Department said Syria's air strike on the hospital in Aleppo was "reprehensible," and it called on Russia to use its influence to pressure Syrian President Bashar al-Assad's government to stop the attacks.

"Once again we call on the regime to cease these absolutely senseless attacks, which are of course violations of the cessation of hostilities," State Department spokesman John Kirby said.

A State Department official said there were indications that the bombing of the hospital was conducted solely by the Syrian government.

US Secretary of State John Kerry said Russia had an urgent responsibility to press the government of its ally Assad to stop attacking civilians and observe the ceasefire.

The Geneva talks aim to end a war that has created the world's worst refugee crisis, allowed for the rise of Islamic State and drawn in regional and major powers, but the negotiations have all but failed and a truce to allow them to take place has collapsed.

Winding up the latest round of talks, de Mistura said he aimed to resume them in May, but gave no date.

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