More than 100 twisters were spotted across the region, according to the National Weather Service, which reported seven casualties in North Carolina.

Three people in Raleigh were killed in mobile homes that were destroyed, the weather service said. It reported two people died near Ammon, North Carolina. One person was killed in the Bladenboro area and another in the Benson and Black Creek area, the weather service said.

North Carolina State Rep. Mike Stone reported two additional deaths in Lee County.

The "destructive" and "extremely dangerous" tornado had barreled into North Carolina early Saturday evening, prompting emergency warnings for much of the central part of the state.

Two rotating storms triggered tornado watches and warnings up through the Richmond, Virginia, Washington and Baltimore areas, according to the National Weather Service.

Meanwhile, emergency crews in Georgia, Mississippi and Alabama worked to assess the damage as the storm system moved north through the Carolinas and up into southern Virginia.

On Friday, Alabama Gov. Robert Bentley declared a state of emergency after reports of tornado touchdowns in at least six counties.

Multiple injuries were reported in Sumter and Marengo counties, with at least one fatality in the latter, he said.

Three people were also killed in Autauga County after fallen trees crashed into mobile homes in the area, police said.

Three additional deaths were reported in Washington County, said Yasamie August, spokeswoman for the Alabama Emergency Management Agency.

Two other deaths were previously reported in Oklahoma and seven in Arkansas.

In Greene County, Mississippi, one death and six injuries were reported, officials said.

Flood warnings were issued across portions of western Alabama Saturday, as earlier rains raised water levels along the Tombigbee River, the weather service said.

Mississippi Lt. Gov. Phil Bryant and Oklahoma Gov. Mary Fallin also declared states of emergency Friday for 14 Mississippi counties and 26 Oklahoma counties, respectively.