Despite US lawmakers' concerns that Egypt is lagging on democratic reforms, Egypt remains one of Washington's closest security allies in the region.
"The launching of the strategic dialogue today is a serious chance for the two sides to review the different parts of the Egyptian-American relationship, politically, militarily and economically and assessing this relationship in all respects," Egyptian Foreign Minister Sameh Shukri said in his opening remarks.
Shukri said he hoped the dialogue would "deepen" bilateral cooperation between the two countries.
Relations had cooled after Mursi of the Muslim Brotherhood was overthrown by the military in 2013 after mass protests against his rule, but ties with former general Abdel Fattah al-Sisi, who was later elected to succeed him, have steadily improved.
The countries last held wide-ranging strategic talks in Dec. 2009.