Three cruisers, the Germini, Costa Victoria and Volendam, will dock at Tien Sa Port for exploring destinations in the city as well as Hoi An and Hue.
Meanwhile, 14,000 visitors will land in the city via direct and chartered flights. The department will present lucky money to the first visitors at the port and airport.
According to the department, 64,000 tourists have already booked rooms at resorts and hotels during the nine-day Tet festival.
Nearly 263,000 tourists visited the city last month, an increase of 13 percent compared to the same period last year.
International tourists accounted for 112,000 visitors, an increase of 3.5 percent year-on-year, while the rest were domestic tourists, up 22 percent, according to the department.
In 2014, Danang hosted four million tourists, including one million foreigners.