It said the first flight will take off from Bangkok at 11am on May 25 and land at Da Nang International Airport around 12.35pm.
The return flight will leave from Da Nang at 13.35pm and arrive in Bangkok at 15.15pm.
As scheduled, the flight will be operated on Monday, Wednesday, Friday and Saturday with 144 Economy class seats on an Airbus 319.
The direct flight route operation from Bangkok to Da Nang was a result of the co-operation and investment in tourism and trade between the city and Thai General Consul in HCM City from 2012.
In February, travel firm Viettravel also offered direct charter flights between the city and Bangkok on Thai Vietjet in order to boost tourism between the central region of Vietnam and Thai destinations.
According to the city, import-export turnover between Thailand and Da Nang reached US$30.2 million, of which US$28.5 million were exports from Thailand.
Thailand has only had one investment project in Da Nang so far with total value of US$10,000.
The central city attracts around 700 tourists from Thailand annually.
Da Nang has hosted the annual East-West Corridor Trade Fair since 2007, which attracted businesses from Thailand, Myanmar, Laos and Vietnam.
Da Nang, which is situated at the end of the East-West Economic Corridor – linking Myanmar, Thailand, Laos and Vietnam, is connected by 19 international routes with over 4 million tourists in 2015.